Table 1 Fixed parameters in the simulation design
From: An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies
Parameter | Description |
|---|---|
S | Number of CpGs chosen to be associated with phenotype in simulation |
μ k | Mean of the cell-type-specific DMS effects for cell type k, over all S DMSs |
σ k | Standard deviation of cell-type-specific DMS effects for cell type k, over all S DMSs |
σ jk | Variability of individual deviations at probe j in cell type k |
\(\alpha ^{(0)} = \left (\alpha _{1}^{(0)}, \alpha _{2}^{(0)}\right)^{\top }\) | Expected proportion of the mixture from cell types 1 and 2 when the phenotype z i is zero. |
\(\alpha ^{(Z)} = \left (\alpha _{1}^{(Z)}, \alpha _{2}^{(Z)}\right)^{\top }\) | Average cell-type mixture proportions for cell types 1 and 2 for subjects with phenotype level Z (continuous or binary) |
ρ | Precision of simulated cell mixture distributions. A greater value corresponds to more clearly defined differences in cell-type proportions with respect to the phenotype |