An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies

Table 3 Performance metrics under simulation scenario 1 (distinct associations between cell types)

Method	Number of false positives	Power	KS	GIF	\(\hat {K}\) ^a
Unadjusted	248	0.208	0.168	1.60	–
Ref-based	14	0.146	0.026	0.92	–
Ref-free	375	0.248	0.097	1.33	13
SVA	32	0.124	0.021	1.05	10
ISVA	14	0.134	0.004	0.97	12
EWASher	3	0.036	0.044	0.92	–
CellCDec	7	0.094	0.008	0.98	–
Deconf	13	0.178	0.023	0.93	–
RUV	36	0.170	0.018	1.04	43

ISSN: 1474-760X